Sensitivity, specificity, positive and negative predictive values, efficiency, area under The Mentzer index showed good sensitivity, specificity, and Youden’s index values of 98.7%, 82.3%, and 81%, respectively. In another study involving 284 patients (130 with IDA and 154 with beta TM), Ehsani et al. Mentzer index OR value was 2.4 (0.5 - 11.5, CI95%). The cut-off point that was recommended for Indonesian population was 10.7 with 81.6% sensitivity … Diagnoses associated with Mentzer index and the sensitivity and specificity for each. Sensitivity, specificity and Youden’s index were compared between the proposed index and four other indices, namely England-Fraser, Mentzer, Srivastava and RBC count. The Green King index showed a highest sensitivity of 100% but a very The Sensitivity of Mentzer index was 84.6% in George Klee et al study [9], 88.7% in Nishi madan et al study [16], and 85.3% in sreekantha et al [12]. By this study's cut-off, the G&K and RDWI showed the highest accuracy, sensitivity, and specificity. Thalassemia: Sensitivity and Specificity. There are a number of different 'indices' that one can use to distinguish IDA from thalassemia (see below), but iron studies / ferritin are probably more accurate. index (sensitivity + specificity– 100) for each of these indices to diagnose IDA, which, by taking into account both sensitivity and specificity,measures their validity to diagnose IDA versus AT. Results: The sensitivity and specificity of Mentzer’s index in differentiating thalassemia from IDA is 39.06% and 79.86% respectively. P-values were obtained using ANOVA analysis implemented in the statistical software SPSS 13.0. The highest sensitivity was noted by the Shine and Lal index (88.16%). The highest specificity was noted by the Mentzer index (88.0%). A high Youden value for a test makes it Conclusion: Mentzer index is a not a reliable marker in diagnosis of thalassemia as it has low sensitivity and specificity. All the parameters are statistically significant (p value<0.001). In each case we must perform comparisons between all anemias and healthy patients, as well as comparisons between the two anemia subtypes. Table 1 presents the descriptive statistics of the 384 patients analyzed in our retrospective study. Mentzer index showed the low sensitivity of 60% but highest specificity of 93.10% .England Fraser index had a lowest Sensitivity of 20% but high Specificity of 86.21%, while RBC count had Sn of 40% and specificity of 65.52%. Positive predictive value (PPV sensitivity, specificity), negative predictive value (NPV), and Youden's index were analyzed for individual measure. The Youden's index takes into account both sensitivity and specificity and therefore provides a reliable measure to determine that validity of a technique. CONCLUSION: The new cut-off of erythrocyte index and its calculation to screen hemoglobinopathy in Indonesia showed a higher sensitivity and specificity, especially for G&K and RDWI with cut-off 73 and 228, respectively. CONCLUSION: MCV≤59.9 fL and Mentzer Index≤12.45 were the best discriminating indices obtained with high sensitivity, NPV, YI and ARUC. Youden’s index was found to be highest for the Shine and Lal index. No test or parameter though, had a 100 % sensitivity or specificity. Synonyms for Mentzer index in Free Thesaurus. Therefore, the RBC count is normal with a low MCV and the Mentzer's index is <13. Talking about RDW, some have Mentzer index in this study showed sensitivity of 42.86% with highest specificity i.e. Statistical analysis of data was done by SPSS 16 software. The study resulted in 60.5% sensitivity, 28.6% specificity, 82.1%, positive predictive value, 11.8%, negative predictive value, 0.9 positive likelihood ratio, and 11.8%, negative likelihood ratio for MI in diagnosing IDA. according to Youdens index. Youden's index is the most reliable method by which to measure the validity of a particular technique, because it takes into account both sensitivity and specificity. Some have reported a lower sensitivity of 67% in Mentzer’s index while other studies have shown higher sensitivity with this index (82–95%) [11-14].This study showed sensitivity and specificity of RDW as 7.94% and 92.29% respectively . The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which … Some have reported a lower sensitivity of 67% in Mentzer’s index while other studies have shown higher sensitivity with this then sensitivity and specificity of King-Green, Mentzer index, England and Fraser, Shine and Lal, Srivastava and Sirdah formulae were investigated. Garg et al showed specificity of this index as 94.8%. Batebi et al [10] reported sensitivity and specificity of Mentzer index as 86.3% and 85.4% respectively. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Introduction: Thalassemia is in the differential diagnosis of a microcytic anemia. Overview of Historical Data. Some showed considerable sensitivity for IDA or TT, but not specificity [5]. The Mentzer index showed good sensitivity, specificity, and Youden’s index values of 98.7%, 82.3%, and 81%, respectively. 99.66% (Table 3). The Sensitivity, Specificity, PPV and NPV of Mentzer index are 83.05%, 97.36%, 96.07% and 88.09% respectively in current study. Table 2: Sensitivity, Specificity and Efficiency of NESTROFT and other discriminative indexes for the diagnosis of BTT Test/index Sensitivity (%) Specificity (%) Efficiency (%) NESTROFT 100 78.94 84.61 Mentzer Index 92.85 86.84 88.46 Srivastava Index 100 63.14 73.07 Shine & Lal Index … Some have reported a lower sensitivity of 67% in Mentzer’s index while other studies have been higher with this index (82–95%) [9-12]. Eight common discrimination formulas are used, such as Mentzer Index (MI), 20 England & Fraser Index (E&F), 21 Shine and Lal formula (S&L), 22 Ehsani formula (EF), 23 Srivastava formula, 24 Palestinian population (PP), 25 Green & King Index (G&K), 26 and RDW Index (RDWI). When the Mentzer index was calculated, 264 children with microcytic anemia (91%) were correctly diagnosed. Mentzer index could be used to predict the diagnosis of beta-thalassemia carrier. The values for each discrimination index were applied as used in the original published reports: Mentzer index, the Shine and Lal index, MCI, and RBC count and RDW were evaluated and compared. Shine and Lal index showed the highest sensitivity (100%) and the highest negative predictive value (100%) but its specificity was low (45.5%) and had 12 (54%) false positives. These indices were applied on 47 patients with βTT and on 289 patients with IDA, as confirmed by gold standard tests. In this study, King-Green formula was reported to have the highest sensitivity and specificity, which as a result, was the most reliable formula followed by Mentzer formula. Matos et al., [6] reported that its sensitivity was 99.3%, Specificity 76.7% and YI was 76.0%, and the evaluation of this index by Arora et al., [22] showed high sensitivity to detect IDA (98.81%), excellent diagnostic accuracy and showing good applicability as screening tool in clinical practice. It is also important to note that the test has a high sensitivity and low specificity. index) for each discriminating index. The two other categories of microcytic anemia are Iron Deficiency Anemia and Anemia of Chronic Disease. Sensitivity Specificity PPV NPV +ve LR -ve LR Accuracy YI MI βTT 68.96 63.88 50.63 88.46 1.9 0.48 65.66 32.84 Antonyms for Mentzer index. The Youden's Index introduces the least bias to the measure of effect (13). In a lot of cases, the index may fall in between 11 and 13, such cases a peripheral blood smear and iron studies would help to differentiate iron deficiency from thalassemia. However, none of these indices showed a sensitivity and specificity of 100% in prediction of IDA and TT. When the Mentzer index was calculated, 264 children with microcytic anemia (91%) were correctly diagnosed. 13%, the sensitivity, specificity and accuracy of our Mentzer’s Index and RDW index were appreciatively high in comparison to other studies regarding the two. Mentzer Index (MI), Shine and Lal Index (SLI), Ehsani Index (EI), and Sirdah Index (SI), were evaluated. The sensitivity and specificity of red blood cell count (RBC) alone in diagnosing BTT were 62.9% and 66.7%, respectively. Youden's index provides an appropriate measure of validity of a particular technique or question by taking into account both sensitivity and specificity [6,7].

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